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A clinical study about effectiveness of single dose Fluconazole (Diflucan) therapy in vaginal candidiasis has been carried out in 33 patients who visited Department of Obstetrics and Gynecology, Chonbuk National University Hospital form February 1st, 1991 to September 30th, 1991. Ages ranged from 28 years to 60 years with a mean of 37.7 years and the mean height was 157.1 cm and the mean body weight was 53.0kg. The majority of contanception methods (69.7%) were IUD and surgically sterilized methods. The most offending organism was Candida albicans (88%). The subjective symptoms such as discharge, pruritus, burning were ameliorated after treatment in 81.5%, 76.9% and 100%, respectively. The clinical signs such as erythema, excoriation, erosion and discharge were ameliorated after treatment in 85.0%, 91.7%, 71.4% and 73.3%, respectively. Ninety-one percent(30/33) of patients treated with the single dose were found to be cured at the 1-week follow-up, and this persisted in 93.1%(27/29) of patients to the 4-week follow up. There were no undesirable side effects in all patients during and after treatment. Fluconzole may become the orally active antifungal agents capable of treating vaginal candidiasis with single dose therapy.
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